Madonna with Child between Sts. Flavian and Onuphrius by Lorenzo Lotto. Seen at Galleria Borghese, Rome. Dated 1508. The painting features the Madonna and Child in the center, flanked by St. Flavian and Onuphrius. Saint Flavian offers Jesus a pierced heart, symbolizing the Passion of Christ. Saint Onuphrius known as a hermit saint is depicted with a long beard and wearing minimal clothing, reflecting his life of solitude and penance in the desert. Lorenzo Lotto (c. 1480 – c. 1557) was an Italian painter, draughtsman, and illustrator of the Venetian school during the Renaissance. Born in Venice, Lotto traveled and worked in various cities across Italy, including Treviso, Bergamo, and Ancona.